When choosing or editing a gaming or anime PFP, focus on a strong silhouette...

https://noon-wiki.win/index.php/Why_Do_Some_Gaming_Icons_Look_Clear_Even_With_Lots_of_Art_Behind_Them%3F

When choosing or editing a gaming or anime PFP, focus on a strong silhouette and high contrast to keep it clear at small sizes. Crop tightly around the face and use a simple background without text to avoid clutter